VERONICA KANE DICKSON
BSc Hons University of Ottawa
PhD Sidney Sussex College, University of Cambridge

 

cv / resume

CURRICULUM VITAE
Personal Details

Full name Dr. Veronica Kane Dickson
Email biochem@vkanedickson.com


Education

2002-2005 PhD Biochemistry
Sidney Sussex College, University of Cambridge
MRC Dunn Human Nutrition Unit
(degree conferred May 2006)
1997-2001 BSc. (Hons) Biochemistry
University of Ottawa
Graduated Magna cum Laude
Research Experience

2015-present
Research Associate
Cambridge Institute for Medical Research
Supervised by Paul Luzio Expression and purification of integral membrane proteins
2008-2013
MSKCC Post-doctoral Fellow
Sloan-Kettering Institute, Structural Biology Department
Supervised by Dr. S. B. Long
Structure and function studies of the eukaryotic Ca2+-activated Cl- channel bestrophin
2005-2008 MRC Career Development Fellowship (Post-doctoral position)
MRC Dunn Human Nutrition Unit, Cambridge
(Recently renamed MRC Mitochondrial Biology Unit)
Supervised by Prof. Sir. John Walker
Structure-function studies of the small membrane subunits in the stator domain of the mitochondrial ATP synthase
2002-2005 PhD student, MRC Studentship
MRC Dunn Human Nutrition Unit, Cambridge
Supervised by Prof. Sir John Walker
Structural studies of the stator of the mitochondrial ATP synthase
2001 Research assistant
University of Ottawa, Ottawa, Canada and
NRC Bioinformatics Research Institute, Montreal, Canada
Supervised by Prof. I. Altosaar and Dr. F. Ni
2000-2001 Honours research student
University of Ottawa, Ottawa, Canada
Supervised by Prof. John E. Baenziger
Polarized Fourier Transfer Infrared (FTIR) difference spectroscopy of the nicotinic Acetylcholine receptor
Supervisory Experience

Summer 2007 Supervision of an undergraduate summer student within the laboratory
Involved project design, teaching laboratory techniques for cloning, over-expression and purification of recombinant protein, evaluations, and administration of the project.
2000-2001 Chemistry laboratory teaching assistant
Involved overseeing 18 first year science students in weekly inorganic chemistry practicals (3 hours), marking weekly reports and short quizzes, and tutoring on the topics covered.


Awards and honours

2008 University of Alberta travel award (CDN$ 1800)
2007 Membrane Proteins Masterclass presentation awards (€200)
2006 GRC selected poster (select posters chosen to give seminar on presented work)
2005 GRC selected poster
2003 PhD 2nd year poster presentation awards, first prize
2001 Honours poster presentation awards, first prize (CDN$ 50)
1997 Entrance scholarship, University of Ottawa (CDN$ 2500)


Boards and committees

2009-2012 MSKCC Research Fellow Advisory Council, RFAC (invited)
2009-2011 MSKCC Post-doctoral Symposium - Peer reviewer
2010 MSK-PDA Executive Committee Member (appointed)
2009 MSKCC Post-doctoral Symposium Committee
2009 MSK-PDA Communications Co-chair (elected)
2005-2006 MRC-Dunn PDA Executive Committee Member (appointed)


Select Presentations

Jan. 2015 CCP4 Study Weekend, Nottingham, UK
Phasing and structure of a pentameric anion chnnel-Fab complex using tantalum bromide clusters
Dec. 2008-2013 Regular group meetings including weekly summaries and bi-monthly formal presentations
June 2006 Gordon Research Conference in Molecular and Cellular Bioenergetics, Andover, NH, USA.
Structure of the peripheral stalk of mitochondrial F1Fo ATP synthase as determined by X-ray crystallography (poster and short seminar)
Oct. 2005 MRC Dunn Human Nutrition Unit Annual Symposium.
The structure of the peripheral stalk of mitochondrial ATP synthase
June 2005 Gordon Research Conference in Molecular and Cellular Bioenergetics, Biddeford, ME, USA.
Structural model of the peripheral stalk of mitochondrial F1Fo ATP synthase
May 2005 MRC Dunn Human Nutrition Unit
PhD Summary Unit Talk
The peripheral stalk of the ATP synthase - tying it all together
Research Interests

  • Structural studies of membrane proteins; three-dimensional protein crystallography, electron microscopy, spectroscopic methods.
  • Ion channels, neurotransmission; allosteric activation and gating, regulation of receptor presentation by protein trafficking, role in anxiety disorders and addictions.
  • Lipid-protein interactions, protein stability and folding, molecular dynamics.

Publications

Kane Dickson, V. (2016) Phasing and structure of Bestrophin-1; a case study in the use of heavy atom cluster compounds with multi-subunit membrane proteins. Acta Crystallogr. D72, 319-325.

Kane Dickson, V., Pedi, L. and Long S.B. (2014) Structure and insights into the function of a Ca2+-activated Cl- channel. Nature. 516, 213-218
- see also related News and Views article (Whorton, M.) Nature. 516, 176-178

Kane Dickson, V., Silvester, J.A., Fearnley, I.M., Leslie, A.G.W., and Walker, J.E. (2006) On the structure of the stator of the mitochondrial ATP synthase. EMBO J., 25, 2911-2918.

Silvester, J.A., Kane Dickson, V., Runswick, M.J., Leslie, A.G.W., and Walker, J.E. (2006) The expression, purification, crystallization and preliminary X-ray analysis of a subcomplex of the peripheral stalk of ATP synthase from bovine mitochondria. Acta Crystallogr. F62, 530-533.

Walker, J.E. and Kane Dickson, V. (2006) The peripheral stalk of the mitochondrial ATP synthase. Biochem. Biophys. Acta. 1757, 286-296.

Rubinstein, J.L., Kane Dickson, V., Runswick, M.J., and Walker, J.E. (2005) ATP synthase from Saccharomyces cerevisiae: Location of Subunit h in the Peripheral Stalk Region. J. Mol. Biol. 345, 513-520.

Baenziger, J.E., daCosta, C.J.B., and Kane Dickson, V. (2005) Membrane Receptor-Ligand Interactions Probed by Attenuated Total Reflectance Infrared Difference Spectroscopy. In Vibrational Spectroscopy of Biological and Polymeric Materials (Gregoriou, V. and Braiman, M.), pp. 325-352. Taylor and Francis Group. Boca Raton, FL.